Anti-14-3-3 monoclonal antibody, clone 3R359

Antibody Isotype

IgG2a

Clone

3R359

Species Reactivity

Rat

Immunogen

Synthetic peptide, corresponding to amino acids 208-244 of Rat 14-3-3.

Conjugate

Alternative Names

YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; 14-3-3 protein zeta/delta; KCIP-1; protein kinase C inhibitor protein 1; mitochondrial import stimulation factor S1 subunit; 14-3-3z;

Entrez Gene ID

UniProt ID

Antigen Description

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.

Pathway

Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; GP1b-IX-V activation signalling, organism-specific biosystem; Hemostasis, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem;