Anti-14-3-3 monoclonal antibody, clone 71D21

Antibody Isotype

IgG2b

Clone

71D21

Species Reactivity

Human

Immunogen

Recombinant Human 14-3-3 purified from E. coli.

Conjugate

Application Notes

WB: 1/2000; IHC-P: 1/200;

Alternative Names

YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein, alpha polypeptide , YWHAA; 14-3-3 protein beta/alpha; 14 3 3 alpha; 14 3 3 beta; 14-3-

Entrez Gene ID

UniProt ID

Antigen Description

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.

Pathway

ARMS-mediated activation, organism-specific biosystem; Activation of BAD and translocation to mitochondria, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Axon guidance, organism-specific biosystem;