Human AMOT peptide

Specificity

Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.

Nature

Synthetic

Tag/Conjugate

Unconjugated

Alternative Names

The coiled coil domain interacts directly with the BAR domain of ARHGAP17.The angiostatin binding domain (871-1005) allows the binding to angiostatin.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Gene ID

154796

UniProt ID

Q4VCS5

Antigen Description

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Function

angiostatin binding; protein binding; receptor activity;

Synonyms

AMOT; angiomotin; angiomotin p80 isoform; angiomotin p130 isoform;