This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]
Function
hormone binding; identical protein binding; protein heterodimerization activity; protein kinase binding; receptor activity;
Synonyms
ADIPOR1; adiponectin receptor 1; CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A; adiponectin receptor protein 1; progestin and adipoQ receptor family member I;
Citations
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