Anti-AKT1 monoclonal antibody (DMABT-H12610)
Mouse Anti-Human AKT1 monoclonal antibody for WB, IHC, IF, IP, sELISA, ELISA
Datasheet
Specifications
Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3F22
Species Reactivity
Human, Mouse, Rat
Immunogen
AKT1 (AAH00479.1,2a.a. ~ 480 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated
Target
Alternative Names
AKT1; v-akt murine thymoma viral oncogene homolog 1; RAC-alpha serine/threonine-protein kinase; AKT; PKB; PRKBA
Entrez Gene ID
UniProt ID
Product Background
Pathway
AKT phosphorylates targets in the cytosol, organism-specific biosystem; AKT phosphorylates targets in the nucleus, organism-specific biosystem; AKT-mediated inactivation of FOXO1A, organism-specific biosystem; Activation of BAD and translocation to mitochondria, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem;
Citations
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References
Shankar, SL; O'Guin, K; et al. Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis. JOURNAL OF NEUROSCIENCE 26:5638-5648(2006).
Zhu, F; Zhang, YG; et al. Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells. CARCINOGENESIS 25:1847-1852(2004).
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Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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