Anti-AKT1 monoclonal antibody (DMABT-H12610)

Mouse Anti-Human AKT1 monoclonal antibody for WB, IHC, IF, IP, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3F22
Species Reactivity
Human, Mouse, Rat
Immunogen
AKT1 (AAH00479.1,2a.a. ~ 480 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
AKT1; v-akt murine thymoma viral oncogene homolog 1; RAC-alpha serine/threonine-protein kinase; AKT; PKB; PRKBA
Entrez Gene ID
UniProt ID

Product Background


Pathway
AKT phosphorylates targets in the cytosol, organism-specific biosystem; AKT phosphorylates targets in the nucleus, organism-specific biosystem; AKT-mediated inactivation of FOXO1A, organism-specific biosystem; Activation of BAD and translocation to mitochondria, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem;

Citations


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References


Kang, JQ; Chong, ZZ; et al. Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation. MOLECULAR PHARMACOLOGY 64:557-569(2003).
Chen, CC; Stairs, DB; et al. Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. GENES & DEVELOPMENT 26:2154-2168(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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