Human AKR1B10 peptide (DAG-P0151)

Specificity
Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the aldo/keto reductase family.
Cellular Localization
Lysosome. Secreted. Secreted through a lysosome-mediated non-classical pathway.
Procedure
None
Purity
70 - 90% by HPLC.
Format
Liquid
Preservative
None
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
UniProt ID
Antigen Description
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Function
aldo-keto reductase (NADP) activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; protein binding; retinal dehydrogenase activity;
Synonyms
AKR1B10; aldo-keto reductase family 1, member B10 (aldose reductase); HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12; aldo-keto reductase family 1 member B10; ARP; hARP; SI reductase; aldose reductase-like 1; small intestine reductase; aldose reductase-like peptide; aldose reductase-related protein; aldo-keto reductase family 1, member B11 (aldose reductase-like);

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References


Heringlake, S; Hofdmann, M; et al. Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours. JOURNAL OF HEPATOLOGY 52:220-227(2010).
Ma, J; Yan, RL; et al. Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. JOURNAL OF BIOLOGICAL CHEMISTRY 283:3418-3423(2008).

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