Anti-AKR1B10 monoclonal antibody (DMABT-H27002)

Mouse Anti-AKR1B10 monoclonal antibody for ELISA, WB, IP Datasheet

Online Inquiry Add to basket

Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
FI269
Species Reactivity
N/A
Immunogen
HHHHHH peptide conjugated to KLH
Conjugate
Unconjugated

Target


Alternative Names
AKR1B10; aldo-keto reductase family 1, member B10 (aldose reductase); AKR1B11; aldo-keto reductase family 1 member B10; AKR1B12; aldo keto reductase family 1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase)) is a Protein Coding gene. Diseases associated with AKR1B10 include hepatocellular carcinoma and nicotine dependence, protection against. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include aldo-keto reductase (NADP) activity and indanol dehydrogenase activity. An important paralog of this gene is AKR1B1. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
Antigen Description
This polyhistidine epitope tag is generally comprised of six consecutive histidine amino acid residues located at the N-terminal, C-terminal, or internally 1. The 6 His-Tag is widely used because of its affinity to bind nickel or cobalt metal ions attachedActs as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene. 0The function about AKR1B10 antigen include aldo-keto reductase (NADP) activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; protein binding; retinal dehydrogenase activity.
Pathway
Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Galactose metabolism, organism-specific biosystem; Galactose metabolism, conserved biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem.

Citations


Have you cited DMABT-H27002 in a publication? Let us know and earn a reward for your research.

References


Heringlake, S; Hofdmann, M; et al. Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours. JOURNAL OF HEPATOLOGY 52:220-227(2010).
Ma, J; Yan, RL; et al. Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. JOURNAL OF BIOLOGICAL CHEMISTRY 283:3418-3423(2008).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

Customer Reviews


Write a review, share your experiences with others and get rewarded !

Online Inquiry

Name
Phone *
E-mail Address *
Service & Products Interested *
Project Description
Verification Code * Please input "diagnostics" as verification code.

Online Inquiry

Order Info: Anti-AKR1B10 monoclonal antibody

Online Inquiry
  Interested in larger quantities ? request a quote!
  Protocol may be improved. Please feel free to contact us to obtain the latest version.!
  15% off your first purchase

Ordering Information

Payment methods we support:
Invoice / Purchase Order
Credit card

OUR PROMISE TO YOU Guaranteed product quality expert customer support

Inquiry Basket