Mouse Anti-AKR1B10 monoclonal antibody for ELISA, WB, IP
AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase)) is a Protein Coding gene. Diseases associated with AKR1B10 include hepatocellular carcinoma and nicotine dependence, protection against. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include aldo-keto reductase (NADP) activity and indanol dehydrogenase activity. An important paralog of this gene is AKR1B1. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
This polyhistidine epitope tag is generally comprised of six consecutive histidine amino acid residues located at the N-terminal, C-terminal, or internally 1. The 6 His-Tag is widely used because of its affinity to bind nickel or cobalt metal ions attachedActs as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene. 0The function about AKR1B10 antigen include aldo-keto reductase (NADP) activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; protein binding; retinal dehydrogenase activity.
Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Galactose metabolism, organism-specific biosystem; Galactose metabolism, conserved biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem.
Heringlake, S; Hofdmann, M; et al. Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours. JOURNAL OF HEPATOLOGY 52:220-227(2010).
Ma, J; Yan, RL; et al. Aldo-keto reductase family 1 B10 affects fatty acid synthesis by regulating the stability of acetyl-CoA carboxylase-alpha in breast cancer cells. JOURNAL OF BIOLOGICAL CHEMISTRY 283:3418-3423(2008).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.