Specifications
Applications
Application Notes
Suitable for use in pharmacokinetic (PK) assay. Other applications have not been tested but use in such assays should not necessarily be excluded.
Recommended Working Concentration: 0.001-0.1 μg/ml
General Notes
Suitable for use in pharmacokinetic (PK) assay. Other applications have not been tested but use in such assays should not necessarily be excluded.
Ustekinumab with trade name Stelara, is an FDA-approved drug to Crohn's disease, Ulcerative Colitis, Plaque Psoriasis and Psoriatic Arthritis, targeting both interleukins (IL)-12 and IL-23. Ustekinumab is a fully human immunoglobulin G1 kappa mAb that binds to IL-12 and IL-23. Ustekinumab binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes, thereby disrupting the proinflammatory pathway.
Images
ELISA, Immunogenicity assay
CABT-ZB278 binds with Ustekinumab.
Dilution: Start from 1,000 ng/ml, Ec50=9.187 ng/ml.
Coating antigen: Ustekinumab, 1 μg/ml.
Target
Alternative Names
Rabbit polyclonal antibody to Ustekinumab/Stelara; CNTO 1275; Stelara; Ustekinumab
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Varada, S; Gottlieb, AB; et al. Treatment of coexistent psoriasis and lupus erythematosus. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 72:253-260(2015).
Blanco, CP; Cuenllas, BA; et al. Use of ustekinumab in inflammatory bowel disease. apropos of three cases. GASTROENTEROLOGIA Y HEPATOLOGIA 35:451-452(2012).
COA
Certificate of Analysis
