Anti-Human DR3 monoclonal antibody (CABT-L1636)

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
22I7M0
Species Reactivity
Human, Mouse
Immunogen
Peptides corresponding to Human TNFRSF25 (aa 398-414, 29-42)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution:
FC: 5 µg/10^6 cells
ICC: 2 µg/ml
IF: 2 µg/ml
WB: 1-2 µg/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Western blot analysis was performed on whole cell extracts (30 µg lysate) of K-562 (Lane 1), Jurkat (Lane 2), MOLT4 (Lane 3), THP-1 (Lane 4) and Tissue lysates of (30 µg lysate) Mouse Thymus (Lane 5). The blots were probed with Anti-DR3/ TNFRSF25 recombinant rabbit monoclonal antibody and detected by chemiluminescence using Goat anti-Rabbit IgG (H+L) Secondary Antibody, HRP conjugate. Two isoforms of 45 and 13 kDa band corresponding to DR3/ TNFRSF25 was observed across cell lines tested.

Target


Alternative Names
TNFRSF25; tumor necrosis factor receptor superfamily, member 25; DR3; TR3; DDR3; LARD
Entrez Gene ID
UniProt ID

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Schreiber, TH; Wolf, D; et al. Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. JOURNAL OF CLINICAL INVESTIGATION 120:3629-3640(2010).
Meylan, F; Richard, AC; et al. TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation. IMMUNOLOGICAL REVIEWS 244:188-196(2011).

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