Molecular Weight
app. 44 kDa
Alternative Names
sulindac; Clinoril; Arthrocine; Sulindac sulfoxide; Sulindaco; Sulindacum; Aflodac
Purity
chromatography, dialysis
Concentration
1 mg/mL working concentration
Reconstitution
Reconstitute with 1 ml PBS without azide.
Introduction
Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)
Antigen Description
Sulindac, covalently linked to horseradish peroxidase
Keywords
drug-HRP conjugate, drug-conjugate, sulindac HRP conjugate
Citations
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COA
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