Molecular Weight
app. 65 kDa
Alternative Names
sulindac; Clinoril; Arthrocine; Sulindac sulfoxide; Sulindaco; Sulindacum; Aflodac
Purity
chromatography, dialysis
Concentration
1 mg/mL, conjugation ratio is app. 1:10 - 1:40.
Preservative
0.05% sodium azide
Introduction
Sulindac is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)
Antigen Description
Sulindac, covalently linked to bovine serum albumin
Keywords
drug-BSA conjugate, drug-conjugate, sulindac BSA conjugate
Citations
Publication ()
Have you cited DAG306S in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
