Product Overview
This item requires custom production and lead time is between 4-12 weeks. We can custom produce based on your specifications.
Purity
> 85% as determined by SDS-PAGE
Format
Liquid or Lyophilized powder
Storage
Store at -20°C/-80°C upon receipt. Avoid repeated freeze-thaw cycles.
Introduction
Smallpox was an infectious disease unique to humans, caused by either of two virus variants, Variola major and Variola minor. The disease is also known by the Latin names Variola or Variola vera, which is a derivative of the Latin varius, meaning "spotted", or varus, meaning "pimple". The term "smallpox" was first used in Britain in the 15th century to distinguish variola from the "great pox" (syphilis). The last naturally occurring case of smallpox (Variola minor) was diagnosed on 26 October 1977.
Function
Plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities. Blocks also the phosphorylation and subsequent activation of IRF3 and IRF7 kinases that are required for interferon-alpha gene expression. Inhibits NF-kappa-B activation and the ubiquitin-like protein ISG15, which is an early antiviral protein. The binding with host ISG15 subsequently blocks host ISGylation. Inhibits ZBP1-dependent necroptosis via interaction with host ZBP1.
Keywords
Vaccinia virus RNA-binding protein OPG065; RNA-binding protein E3; p25; E3L; VACWR059; VACV
Citations
Publication ()
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COA
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