Product Overview
Squamous Cell Carcinoma Antigen 1 Recombinant Protein with N-terminal GST-tag.
Alternative Names
SERPINB4, PI11, SPB4, Leupin, Peptidase Inhibitor 11
Purity
> 90 % as determined by SDS-PAGE.
Concentration
1 mg/mL (lot specific)
Buffer
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose
Storage
Storage: Store it under sterile conditions at -20°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
Stability
The recombinant protein is stable for up to 6-12 months from date of receipt at -20°C to -80°C.
Introduction
Squamous cell carcinoma antigen (SCCA), a member of the serine protease inhibitor (serpin) family, is a subfraction of the tumor associated antigen TA-4, is a glycoprotein, with a molecular weight between 42 to 48 kDa. Total SCCA in the circulation comprises 2 nearly identical, approximately 45 kDa proteins, SCCA1 and SCCA2. Both proteins are members of the high-molecular weight serine proteinase inhibitor (serpin) family with SCCA1 paradoxically inhibiting lysosomal cysteine proteinases and SCCA2 inhibiting chymotrypsin-like serine proteinases. Although SCCA1 and SCCA2 are detected in the cytoplasm of normal squamous epithelial cells, neither serpin is detected normally in the serum.
Keywords
SERPINB3; HsT1196; SCC; SCCA-1; SCCA-PD; T4-A; Serpin Peptidase Inhibitor; Clade B(ovalbumin); Member 3; Serpin B3
Citations
Publication ()
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