Product Overview
A DNA sequence encoding the human osteopontin protein (a.a.17-166) was expressed with His-tag at the N-terminus
Alternative Names
Osteopontin; OPN; Bone sialoprotein I; BSP-1; BNSP; T lymphocyte activating factor; ETA-1; Secreted phosphoprotein 1; SPP1; Anti-Rick Secondary body; Ric
Purity
> 95% as determined by SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4
Storage
Store at -20°C to -80°C
Introduction
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene.
UniProt ID
NP_001035147.1
Keywords
Osteopontin; SPP1; ETA-1; OPN
Citations
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Ahlberg, V; Bengtsson, KL; et al. Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 38:17-26(2012).
Yuan, YS; Zhang, XY; et al. Expression and Purification of Bioactive High-Purity Recombinant Mouse SPP1 in Escherichia coli. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 173:421-432(2014).
COA
Certificate of Analysis
