Recombinant Human TNFRSF11A Protein [hFc]

Target

TNFRSF11A

Nature

Recombinant

Tag/Conjugate

hFc

Molecular Weight

53.3 kDa

Purity

> 90% as determined by SDS-PAGE

Format

Lyophilized

Buffer

Lyophilized from sterile PBS, pH 7.4

Preservative

None

Storage

Store at -20°C

Ship

Wet ice

Introduction

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone.

Keywords

TNFRSF11A; TNF receptor superfamily member 11a