Product Overview
Recombinant HTLV-I gp46 antigen (a.a. 165-440), contains a His fusion partner at the C terminus, was expressed in E. coli, and puried in vitro using conventional chromatography techniques and High Performance Liquid Chromatography techniques
Purity
> 95% pure (SDS-PAGE and HPLC-C4)
Buffer
10mM Sodium phosphate, pH 6.0 containing 0.1% SDS, 1mM DTT and 1mM EDTA
Storage
2-8°C short term, -20°C long term
Introduction
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
Antigen Description
HTLV I gp46 surface protein is processed from its precursor gp62. It attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane. HTLV-I gp46 antigen (a.a. 165-440) reacts with human HTLV-I/-II positive serum.
Keywords
HTLV-I gp46; Glycoprotein 46; SU; Surface protein; HTLV-I gp46 antigen; Deltaretrovirus; Retroviridae; Human T-lymphotropic virus Type I; T-lymphotropic virus Type I Gp46; HTLV-1; Adult T-cell lymphoma virus type 1; Human T-lymphotropic Virus Type I Gp46
Citations
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