HTLV type 1 Glycoprotein 46 (DAG-P2964)

HTLV type 1 Glycoprotein 46 (aa 165 - 440), recombinant protein from E. coli Datasheet

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Product Overview
HTLV I gp46 protein fragment
Nature
Recombinant
Tag/Conjugate
Unconjugated
Cellular Localization
Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein
Bio-activity
Reacts with Human HTLV I/II positive serum.
Purity
> 95 % by SDS-PAGE.>95% pure (SDS-PAGE and HPLC-C4)
Format
Liquid
Buffer
Preservative: None Constituents: 0.1% SDS, 10mM Sodium phosphate, 1mM DTT, 1mM EDTA, pH 6.0
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. Preservative: None Constituents: 0.1% SDS, 10mM Sodium phosphate, 1mM DTT, 1mM EDTA, pH 6.0
Introduction
The human T-lymphotropic virus type I (HTLV-1) is a human retrovirus that is known to cause a type of cancer, referred to as adult T-cell leukemia and lymphoma, and a demyelinating disease called HTLV-I associated myelopathy/tropical spastic paraparesis (
Antigen Description
HTLV I gp46 surface protein is processed from its precursor gp62. It attaches the virus to the host cell by binding to its receptor. This interaction triggers the refolding of the transmembrane protein (TM) and is thought to activate its fusogenic potential by unmasking its fusion peptide. Fusion occurs at the host cell plasma membrane.
Keywords
Glycoprotein 46; SU; Surface protein; HTLV I gp46

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