Product Overview
cDNAs coding for the mature forms of the human SmD1, SmD2 and SmD3 proteins individually fused to a hexa-histidine purification tag. Expressed by recombinant baculovirus (Autographa califomica multiple nuclear polyhedrosis virus; AcMNPV) infection of Spodoptera frugiperda Sf9 insect cells under conditions promoting symmetrical dimethylation of arginine residues.
Molecular Weight
SmD1: 14 kDa
SmD2: 15 kDa
SmD3: 15 kDa
Alternative Names
SmD; SmD1; SmD2; SmD3
Buffer
Neutral to slightly alkaline pH and 20% glycerol as cryoprotective agent.
Storage
Store at -70°C or below. Repeated freeze/thaw cycles should avoided.
Introduction
In eukaryotic cells, the Sm-proteins B/B', D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. SmD comprises equal masses of SmD1, SmD2, and SmD3. In addition, both SmD1 and SmD3 contain symmetrically dimethylated arginine residues, which represent a major epitope.
Keywords
SmD; D-group Sm protein; Sm snRNP complex
Citations
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