Alternative Names
Small nuclear ribonucleoprotein; Sm D; Sm D3
Purity
>80% as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Storage
2-8°C short term, -20°C long term
Introduction
The Sm antigen is part of the spliceosomal complex catalyzing the splicing of nuclear pre-mRNA. Each spliceosome snRNP consists of snRNAs (U1, U2, U4/U6, and U5) bound to a unique set of proteins as well as a shared set of seven different Sm proteins with molecular weights between 9 and 29.5 kDa (typically SmB/SmB', SmD1, SmD2, SmD3, SmE, SmF, SmG). Most frequently the SmB and SmD polypeptides are targets of the anti-Sm specific autoimmune response, of which SmD is regarded the most SLE-specific Sm antigen.
Keywords
SmD; D-group Sm protein; SmD3; SNRPD3
Citations
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