Product Overview
A DNA sequence encoding the human RP2 (a.a.1-350) was expressed with GST-tag at the N-terminus
Alternative Names
RP2; Retinitis pigmentosa 2 (X-linked recessive); Protein XRP2
Purity
> 90% as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH8.0
Storage
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Introduction
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Keywords
Protein XRP2; RP2
Citations
Publication ()
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COA
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