Recombinant Canine Pancreatic Lipase

Target

PNLIP

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

51.5 kDa

Purity

> 90% as determined by SDS-PAGE

Format

Liquid

Buffer

50mM Tris, 300mM NaCl, pH8.0

Preservative

None

Storage

Store at -80°C. Avoid multiple freeze/thaw cycles.

Ship

Dry ice

Introduction

Pancreatic lipase, also known as pancreatic triacylglycerol lipase, is secreted from the pancreas, and is the primary lipase (enzyme) that hydrolyzes (breaks down) dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Triacylglycerol + H2O diacylglycerol + a fatty acid anion Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resulting monomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsis along the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal. This protein belongs to pancreatic lipase family.

Keywords

Pancreatic lipase; PNLIP; Canine