Target
Ribosomal Phosphoprotein P0
Alternative Names
RPLP0; 60S acidic ribosomal protein P0
Purity
>80% as determined by SDS-PAGE
Concentration
Batch dependent - please inquire should you have specific requirements
Storage
2-8°C short term, -20°C long term
Introduction
The ribosomal phosphoproteins, also called P protein antigens, are associated with the large ribosomal subunit and therefore are antigenic targets with a cytoplasmic localization. Three P proteins have been described: P0 with a molecular weight of 35 kDa, P1 (19 kDa) and P2 (17 kDa). Autoantibodies against ribosomal P proteins are present in 10% of SLE patients. If anti-ribosomal P antibodies were to occur in the absence of other typical SLE associated autoantibodies, they may account for some patients with so-called ANA-negative lupus. It has been reported that lupus patients positive for anti-ribosomal P autoantibodies have a high frequency of CNS involvement, suggesting a marker use for these antibodies.
Keywords
P0; RPLP0; Ribosomal protein P0; Systemic lupus erythematosus; SLE
Citations
Publication ()
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