Human Complement Factor P

Product Overview

Human Complement Factor P (Properdin)

Nature

Native

Tag/Conjugate

Unconjugated

Purity

> 90% by SDS-PAGE

Format

Frozen liquid

Concentration

1.0 mg/ml (see Certificate of Analysis for actual concentration)

Buffer

10 mM Sodium phosphate, 145 mM NaCl, pH 7.3

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Antigen Description

Complement factor P (properdin) is purified from normal human serum. Factor P is a 53,000 dalton cationic protein that circulates in blood in the form of dimers, trimers and tetramers. It binds rapidly to C3b on surfaces where complement has begun to acti

Keywords

complement factor properdin; BFD; PFC; PFD; CFP; properdin; OTTHUMP00000216155; OTTHUMP00000023223; properdin P factor,complement; complement factor P