Magic™ Anti-CRKL (Phospho Y207) monoclonal antibody, clone MAAG4817

Antibody Isotype

IgG

Clone

MAAG4817

Species Reactivity

Human; Mouse

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Tyr207 of human CRKL was used as immunogen. The antibody only detects CRKL phosphorylated on Tyrosine 207.

Conjugate

Application Notes

WB: 1:1000-5000

Alternative Names

CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v crk avian sarcoma virus CT10 oncogene homolog like; crk-like protein;

Entrez Gene ID

UniProt ID

Antigen Description

CRKL (CRK-like), a 36kDa protein predominantly expressed in hematopoietic cell lines, is a member of the CRK adapter protein family. Lacking any intrinsic enzymatic activity, CRKL is composed of one SH2 domain and two SH3 domains. The SH2 domain of CRKL as been shown to interact with c-Cbl, Cas, Hef-1 and Paxillin; while the N-terminal SH3 can bind to c-ABL, Sos1 and C3G. Additionally, the phosphorylated form of CRKL (pY207) binds to BCr-ABL oncogene in chronic myelogenous leukemia cells.

Pathway

B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem;