Purified CEC1-5 (soluble C-cadherin ectodomain) protein
Fusion Species
Mouse X Mouse Hybridoma
Immunological Donor
Mouse spleen
Myeloma
Sp2/0
Clone
BB6
Cell Line Description
Animals were immunized with purified CEC1-5 (soluble C-cadherin ectodomain) protein. Spleen cells were fused with Sp2/0 mouse myeloma cells. C-cadherin is the major cadherin expressed in the blastula and early gastrula and is largely responsible for holding cells in the embryo together. The AA5 antibody is the first antibody that can activate cadherin adhesive function. The AA5 antibody restores strong adhesion to activin-treated blastomeres. The C-cadherin-activating antibody strongly inhibits the elongation of animal caps, in response to activin, without affecting mesodermal gene expression.
Morphology
Lymphoblast
Growth Properties
Suspension
CultureMethod
Storage
Liquid nitrogen vapor phase.
Citations
Publication ()
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