Purity
> 95% as determined by SDS-PAGE
Storage
Store at 2°C to 8°C
Introduction
Endostatin is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. Endostatin is a broad-spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF).
Citations
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Eskens, FALM; et al. Angiogenesis inhibitors in clinical development; where are we now and where are we going?. BRITISH JOURNAL OF CANCER 90:1-7(2004).
Gasparini, G; Longo, R; et al. Combination of antiangiogenic therapy with other anticancer therapies: Results, challenges, and open questions. JOURNAL OF CLINICAL ONCOLOGY 23:1295-1311(2005).
COA
Certificate of Analysis
