Suitable for use to measure free Obinutuzumab in patient samples.
Recommended antibody pair for pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB219 - CABT-ZB220; CABT-ZB219 - CABT-ZB221
Recommended Working Concentration: 0.005-1 μg/ml
Summary
Specifications
Antibody Isotype
IgG1, κ
Clone
29I9
Immunogen
Obinutuzumab
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in PK bridging ELISA. We recommend the following for sandwich ELISA (Capture - Detection): CABT-ZB219 - CABT-ZB220; CABT-ZB219 - CABT-ZB221 Recommended Working Concentration: 0.005-1 μg/ml
General Notes
We recommend the following antibody pair to develop a pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB219 - CABT-ZB220; CABT-ZB219 - CABT-ZB221 CABT-ZB219 is recommended for use as a capture antibody when paired with CABT-ZB220 or CABT-ZB221 as a detection antibody. Obinutuzumab is a humanized anti-CD20 monoclonal antibody, originated by GlycArt Biotechnology AG and developed by Roche as a cancer treatment. It was approved under the trade name Gazyva by the US FDA in 2013, and as Gazyvaro by the EMA in Europe, for the treatment of chronic lymphocytic leukemia in combination with chemotherapy in treatment-naive patients, and as a second line treatment for follicular lymphoma. Obinutuzumab is a fully humanized monoclonal antibody that binds to an epitope on CD20 that partially overlaps with the epitope recognized by rituximab. Obinutuzumab binds to CD20 on B cells and causes these cells to be destroyed by engaging the adaptive immune system, directly activating intracellular apoptosis pathways, and activating the complement system.
Target
Alternative Names
Mouse monoclonal antibody to Gazyva; Afutuzumab; Obinutuzumab; GA 101
Citations
Publication ()
Have you cited CABT-ZB219 in a publication? Let us know and earn a reward for your research.
My Review for Mouse Anti-Obinutuzumab monoclonal antibody, clone 29I9
Creative Diagnostics products are for RESEARCH USE ONLY, please make sure your review is research based.
Required fields are marked with *
Terms and conditions:
We will select high-quality review customers and offer a $30 coupon for your next purchase.
All product reviews must be submitted in the English language.
Creative Diagnostics will not share any personal information of applicants, and all information will be treated with strict confidentiality and will not be sold or disclosed to a third party.
COA
Publication 
Loading ......
