Suitable for use to measure free Obinutuzumab in patient samples.
Recommended antibody pair for pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB222 - CABT-ZB223; CABT-ZB222 - CABT-ZB224
Recommended Working Concentration: 0.01-1 μg/ml
Summary
Specifications
Antibody Isotype
IgG
Clone
9H23
Immunogen
Obinutuzumab
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in PK bridging ELISA. We recommend the following for sandwich ELISA (Capture - Detection): CABT-ZB222 - CABT-ZB223; CABT-ZB222 - CABT-ZB224 Recommended Working Concentration: 0.01-1 μg/ml
General Notes
We recommend the following antibody pair to develop a pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB222 - CABT-ZB223; CABT-ZB222 - CABT-ZB224 CABT-ZB222 is recommended for use as a capture antibody when paired with CABT-ZB223 or CABT-ZB224 as a detection antibody. Obinutuzumab is a humanized anti-CD20 monoclonal antibody, originated by GlycArt Biotechnology AG and developed by Roche as a cancer treatment. It was approved under the trade name Gazyva by the US FDA in 2013, and as Gazyvaro by the EMA in Europe, for the treatment of chronic lymphocytic leukemia in combination with chemotherapy in treatment-naive patients, and as a second line treatment for follicular lymphoma. Obinutuzumab is a fully humanized monoclonal antibody that binds to an epitope on CD20 that partially overlaps with the epitope recognized by rituximab. Obinutuzumab binds to CD20 on B cells and causes these cells to be destroyed by engaging the adaptive immune system, directly activating intracellular apoptosis pathways, and activating the complement system.
Target
Alternative Names
Rabbit monoclonal antibody to Gazyva; Afutuzumab; Obinutuzumab; GA 101
Citations
Publication ()
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