New Products

Recombinant HPV L1 VLP

Creative Diagnostics has established a global-leading virus-like particles (VLPs) manufacture platform using E. coli cell system. With years of exploration, our scientists have successfully obtained various highly purified HPV VLPs. Our products have significantly contributed to the HPV vaccine related research.

HPV VLPs can be typically used for:

  • Antibody discovery
  • Vaccine development
  • Diagnostic reagent development
  • Protein-based assays, e.g. ELISA

Product List

Catalog# Product Description Expression System Application
DAGF-227 Recombinant HPV type 6 L1 protein (VLP) E. Coli ELISA, Antibody Detection
DAGF-228 Recombinant HPV type 11 L1 protein (VLP) E. Coli ELISA, Antibody Detection
DAGF-229 Recombinant HPV type 16 L1 protein (VLP) E. Coli ELISA, Antibody Detection
DAGF-230 Recombinant HPV type 18 L1 protein (VLP) E. Coli ELISA, Antibody Detection
DAGF-231 Recombinant HPV type 31 L1 protein (VLP) E. Coli ELISA, Antibody Detection
DAGF-232 Recombinant HPV type 33 L1 protein (VLP) E. Coli ELISA, Antibody Detection
DAGF-233 Recombinant HPV type 45 L1 protein (VLP) E. Coli ELISA, Antibody Detection
DAGF-234 Recombinant HPV type 52 L1 protein (VLP) E. Coli ELISA, Antibody Detection
DAGF-235 Recombinant HPV type 58 L1 protein (VLP) E. Coli ELISA, Antibody Detection

>HPV L1 Antibodies for Neutralization and Vaccine Development

What is HPV?

Recombinant HPV L1 VLP Human papillomavirus (HPV) associated cancers include those of the cervix, vulva, vagina, penis, anus, rectum and oropharynx. Because over 80% of all HPV associated cancers occur in the cervix, nearly all of the evidence for prophylactic vaccine prevention of incident type specific HPV infection are in cervical disease.

  • Non-enveloped dsDNA virus.
  • Infectious cycle only in squamous epithelia.
  • Common virus with >100 types identified.
  • 30–40 infect the genital area of women and men.
  • Low risk types causing warts: HPV 6, 11.
  • High risk types causing cancer: 15 oncogenic types. HPV 16, 18 – most important.

Recombinant HPV L1 VLP There are two virus capsid proteins L1 and L2

  • Each virus shell consists of 72 pentamers, each one made of five L1 molecules.
  • L2 sits in the centre of each pentamer.

The neutralizing antibodies are directed against the HPV L1 capsid protein in the native conformation.

  • HPV cannot be grown in bulk in culture so traditional virus vaccines made from live or killed virus are not possible.
  • Prophylactic HPV vaccines are subunit protein vaccines comprised of the L1 protein assembled into virus like particles (VLPs), empty protein shells almost identical to the virus particle.
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