Product Overview
Recombinant Mouse PDCD6IP / ALIX produced in E. coli aa 1-239 with His-T7 tag(s).
Molecular Weight
30.3 kDa
Endotoxin
<1.0EU per 1μg (determined by the LAL method)
Alternative Names
programmed cell death 6 interacting protein; PDCD6IP; AIP1; ALIX; DRIP4
Buffer
Lyophilized from PBS, pH 7.4, 1 mM DTT, 5% Trehalose, 0.01% Sarcosyl, ProClin™ 300
Storage
Store at 4°C for up to 1 month, or aliquot and store at -80°C for up to 1 year. Avoid freeze-thaw cycles.
Reconstitution
Reconstitute in sterile PBS, pH 7.2-7.4.
Introduction
Programmed cell death 6-interacting protein also known as ALIX is a protein that in Mouses is encoded by the PDCD6IP gene. This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.
Keywords
programmed cell death 6 interacting protein; PDCD6IP; AIP1; ALIX; DRIP4
Citations
Publication ()
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