Recombinant Human PDCD6IP [His, GST]

Product Overview

Glu174~Val383 with N-terminal His and GST Tag

Target

Human PDCD6IP

Nature

Recombinant

Tag/Conjugate

His, GST

Molecular Weight

53.8kDa

Endotoxin

<1.0EU per 1μg (determined by the LAL method)

Alternative Names

programmed cell death 6 interacting protein; PDCD6IP

Purity

> 95%

Format

Lyophilized

Buffer

PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

Preservative

Proclin300

Introduction

Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene. This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.

Keywords

programmed cell death 6 interacting protein; PDCD6IP