Recombinant JEV gE Protein [His]

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

40kDa

Alternative Names

Japanese Encephalitis Virus; JEV; JEV gE; JEV envelop protein; JEV EP

Purity

> 90% as determined by SDS-PAGE

Format

Liquid

Buffer

0.01 M PBS

Preservative

None

Storage

Store at 4°C.

Introduction

The Japanese encephalitis virus (JEV) is a flavivirus and is related to the West Nile Virus. JEV is the main cause of viral encephalitis in many countries of Asia with an estimated 68 000 clinical cases every year. Although symptomatic Japanese encephalitis (JE) is rare, the casefatality rate among those with encephalitis can be as high as 30%. Permanent neurologic or psychiatric sequelae can occur in 30%–50% of those with encephalitis.
Flaviviruses are positive-stranded RNA viruses with a 9-12- kb genome that is translated as a single polyprotein and then cleaved by host and viral proteases into structural capsid (C), premembrane (prM), envelope (E) proteins and seven nonstructural proteins. Capsid binds to viral RNA to form a nucleocapsid that is enveloped by an endoplasmic reticulum-derived membrane containing E and prM. E proteins are responsible for cellular attachment and possess a hydrophobic loop that mediates fusion of viral and host membrane.The E protein is therefore the primary target of neutralizing antibodies

Keywords

Japanese Encephalitis Virus; JEV; JEV gE; JEV envelop protein; JEV EP