Japanese encephalitis E glycoprotein; Japanese encephalitis envelope glycoprotein; Japanese encephalitis virus envelope glycoprotein; JEV E glycoprotein; JEV envelope glycoprotein; Major envelope protein E
Product Background
Antigen Description
Japanese encephalitis virus E glycoprotein is one of three structural proteins encoded by the viral genome. It is thought to be involved in viral adhesion and entry into host cells, hemagglutination, cellular tropism, viral virulence, and the induction of protective immune responses. Glycoprotein E is a class II viral fusion protein that mediates both receptor binding and fusion. Glycoprotein E is comprised of three domains: domain I (dimerisation domain) is an 8-stranded beta barrel, domain II (central domain) is an elongated domain composed of twelve beta strands and two alpha helices, and domain III (immunoglobulin-like domain) is an IgC-like module with ten beta strands. Domains I and II are intertwined. Domain II can be divided into two structural components, both of which comprise alpha-beta sandwich folds.
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