The original antibody was isolated using phage display from the IgM+ memory B cells of a healthy individual vaccinated against influenza.
Conjugate
unconjugated
Applications
Application Notes
The antibody neutralizes the virus by blocking conformational rearrangements associated with membrane fusion. CR6261 neutralizes multiple influenza subtypes, including H1, H2, H5, H6, H8, and H9, and protects mice from lethal challenge with H1N1 and H5N1 viruses when administered up to five days post-infection.
Target
Alternative Names
Influenza A virus; Influenzavirus A; IAV; Influenza A; IAV HA; H1N1; H5N1; H1N1 HA; H5N1 HA
Citations
Publication ()
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COA
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