Product Overview
C-terminal 6xHis tagged HA(A/Hong Kong/2108/03(H9N2))protein (a.a.18-522)
Format
Each vial contains 100 μg purified protein in PBS.
Storage
2-8°C short term, -20°C long term
Introduction
Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a
Antigen Description
Hemagglutinin (HA) is a single-pass type I integral membrane glycoprotein from the influenza virus, and comprises over 80% of the envelope proteins present in the virus particle. The HA is a trimer with a receptor binding pocket on the globular head of each monomer. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. Binding of HA to sialic acid-containing receptors on the surface of its target cell brings about the attachment of the virus particle to the cell and forms a endosome. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the hydrophobic portion "fusion peptide". After which, virus penetrates the cell and pours its contents including the RNA genome into the cytoplasm mediated by fusion of the endocytosed virus particle's own membrane and the endosomal membrane. Hemagglutinin plays a major role in the determination of host range restriction and virulence.
Keywords
Influenzavirus A; Influenza A virus; Influenza A virus H9N2 HA; H9N2 HA; H9N2 HA
Citations
Publication ()
Have you cited DAG2185 in a publication?
Let us know and earn a reward for your research.
COA
Loading ......
