Native IAV H3N2 (A/Kiev/301/94) Antigen

Name: Native IAV H3N2 (A/Kiev/301/94) Antigen
SKU: DAG3344
Rating: 5 (1 reviews)

Native IAV H3N2 (A/Kiev/301/94) Antigen from embryonated eggs

COA

SDS

Datasheet

Summary

Product Overview

Influenza A Virus H3N2 Kiev

Specificity

Allantoic fluid of 10 days old embryonated eggs, inoculated with influenza A virus, strain A/Brisbane/10/07. The Influenza Virus was purified by Ultracentrifugation with 10-40% sucrose gradient. Purity is greater than 90.0% as determined by SDS-PAGE. The

Nature

Native

Tag/Conjugate

Unconjugated

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Influenza A virus causes influenza in birds and some mammals, and is the only species of influenza virus A. Influenza virus A is a genus of the Orthomyxoviridae family of viruses. Strains of all subtypes of influenza A virus have been isolated from wild birds, although disease is uncommon. Some isolates of influenza A virus cause severe disease both in domestic poultry and, rarely, in humans.

Antigen Description

H3N2 is a subtype of the influenza A virus. Its name derives from the forms of the two kinds of proteins on the surface of its coat, hemagglutinin (H) and neuraminidase (N). H3N2 exchanges genes for internal proteins with other influenza subtypes. H3N2 ha

Keywords

Influenzavirus A; Influenza A virus; Influenza A virus H3N2; H3N2; IAV H3N2

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

Influenza Virus Antigens

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Customer Reviews

References

Comparative thermostability analysis of zoonotic and human influenza virus A and B neuraminidase

ARCHIVES OF VIROLOGY

Authors: Evseenko, Vasily A.; Svyatchenko, Svetlana, V; Kolosova, Natalia P.; Kovrizhkina, Valentina L.; Marchenko, Vasiliy Y.; Durymanov, Aleksander G.; Goncharova, Natalia, I; Ryzhikov, Alexander B.

Abstract

Neuraminidase (NA) thermostability of influenza A and B viruses isolated from birds, swine and humans was measured to evaluate its variability associated with host body temperature. The highest 50% inactivation temperature (IT50) was observed with H3N8 avian influenza virus (74 degrees C), and the lowest IT50 was observed with the seasonal human H3N2 virus (45.5 degrees C). The IT50 values of A(H1N1)pdm09 viruses 56.4-58.5 degrees C were statistically higher than that of the prepandemic strain A/Solomon Islands/03/06 (52.5 degrees C). An analysis of Ca2+ binding sites revealed the correspondence of amino acid changes to NA thermostability. This study demonstrates that changes in NA thermostability correspond to differences in host body temperature.

Phylogenetic Inference of H3N2 Canine Influenza A Outbreak in Ontario, Canada in 2018

SCIENTIFIC REPORTS

Authors: Xu, Wanhong; Weese, J. Scott; Ojkic, Davor; Lung, Oliver; Handel, Katherine; Berhane, Yohannes

Abstract

The first Canadian H3N2 canine influenza A outbreak involving an Asian-origin H3N2 canine influenza virus (CIV) began in southwestern Ontario, Canada, in late December 2017. More H3N2 CIV cases were identified in central and eastern Ontario between March and October 2018. Based on epidemiological investigation, 5 clusters were identified (C1, C2, C3a, C3b, and C4); however, the origin of infection has only been revealed for epidemiological cluster C1. Here, we use phylogenetic analyses to unravel the links of virus transmission between the 5 epidemiological clusters and the origin of infection for all epidemiological clusters. Our results demonstrate that the Canadian H3N2 CIV sequences were grouped into four distinct phylogenetic clusters with minimal genetic diversity between these clusters. Large scale phylogenetic analysis of H3N2 CIV from around the globe showed that the Canadian CIVs formed a distinct new clade along with CIVs that have been circulating in the USA since 2017-2018 and in China since 2017. This clade shares a common ancestor of Asian origin. This study concludes that the H3N2 CIV outbreak in Ontario was driven by multiple introductions of South Korean/Chinese-origin H3N2 CIVs over 10 months.