Product Overview
Biotinylated Recombinant Human Vascular cell adhesion protein 1 is produced by our Mammalian expression system and the target gene encoding Phe25-Glu698 is expressed with a Avi, 6His tag at the C-terminus.
Endotoxin
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Alternative Names
Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; CD106; INCAM-100
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Buffer
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/mL. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Introduction
VCAM-1 (CD106, INCAM-110) is a cell adhesion molecule and a member of the immunoglobulin superfamily. It's important function is a recognition of cell-cell. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Keywords
Vascular cell adhesion protein 1; V-CAM 1; VCAM-1; CD106; INCAM-100
Citations
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COA
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