Magic™ Rabbit Anti-Human TJP1 Monoclonal antibody, clone 351261D6

Antibody Isotype

IgG

Clone

351261D6

Species Reactivity

Human

Immunogen

ZO1 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT937 - DMAB-CPT938
Sandwich ELISA: 125-8000 pg/mL

General Notes

This product (Catalog No. DMAB-CPT938) is a rabbit-derived monoclonal antibody raised against human TJP1. It has been affinity purified by Protein A. Tight junction (or zonula occludens) form the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium (PMID: 20066090). ZO-1 (also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells (PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin (PMID: 17418867). ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs (MAGUKs). It is a pivotal tight junction protein and may be involved in signaling mechanisms regulating cell proliferation and differentiation.
DMAB-CPT938 is suitable for use in Sandwich ELISA (125-8000 pg/mL) application.
DMAB-CPT938 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

TJP1; ZO-1; ZO 1; Tight junction protein ZO-1; Tight junction protein ZO 1; Tight junction; zonula occludens

Entrez Gene ID

UniProt ID