Synthetic peptide (17-aa) derived from the N-terminal extracellular region of human Polycystin-1 protein
Conjugate
Unconjugated
Applications
Application Notes
IF:1:100
General Notes
This product (Catalog No. CABT-L1313W) is a mouse-derived monoclonal antibody raised against human PKD1. This antibody exhibits cross-reactivity with PKD1 from mouse and rat. It has been affinity purified by Protein A. Polycystin-1, also known as Transient receptor potential polycystin-1 cation channel (TRPP1), is encoded by the PKD1 gene in human. Polycystin-1 contains a large N-terminal extracellular region, eleven transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Polycystin-1 plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). CABT-L1313W is suitable for use in IF (immunofluorescence) (1:100) application. CABT-L1313W is supplied as a liquid formulation in PBS, pH 7.2, 0.1% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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