Rabbit Anti-Human Polycystin 1 (a.a. 131-230) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

KLH conjugated synthetic peptide derived from human Polycystin 1: 131-230/4303

Conjugate

Application Notes

Flow-Cyt: 1μg/Test

General Notes

This product (Catalog No. CPBT-43616RH) is a rabbit-derived IgG polyclonal antibody raised against human PKD1, targeting the amino acid region 131–230 of the protein. This antibody exhibits cross-reactivity with PKD1 from mouse. It has been affinity purified by protein A. This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.
CPBT-43616RH is suitable for use in flow cytometry (FC) (1 μg/test) application.
CPBT-43616RH is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Autosomal dominant polycystic kidney disease protein 1; PBP; PKD; PKD1; Polycystic Kidney Disease 1; Polycystin 1 Precursor; PKD1; Pc-1; TRPP1; PKD1_HUMAN

Entrez Gene ID

UniProt ID