General Notes
This product (Catalog No. DMAB-CBAS087) is a mouse-derived monoclonal antibody raised against human NEFH. It has been affinity purified by Protein A. The neurofilament heavy polypeptide (NEFH) is a crucial component of neurofilaments, which are intermediate filaments providing structural support in neurons. NEFH plays a significant role in maintaining the integrity of podocytes, specialized cells in the kidney, by preventing injury and detachment, particularly in conditions like focal segmental glomerulosclerosis and membranous nephropathy. In the nervous system, NEFH contributes to the structural support of axons and is involved in the radial expansion necessary for nerve conduction. Mutations in the NEFH gene can lead to neurodegenerative diseases such as Charcot-Marie-Tooth disease type 2CC, characterized by amyloidogenic protein aggregation causing muscle weakness and atrophy. Additionally, NEFH mutations are implicated in amyotrophic lateral sclerosis (ALS), where they disrupt axonal transport, leading to neurodegeneration. These insights highlight the dual role of NEFH in both structural maintenance and disease pathology across different tissues.
DMAB-CBAS087 is suitable for use in ELISA(Det) application.
DMAB-CBAS087 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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