General Notes
This product (Catalog No. DMAB-CBAS055) is a mouse-derived monoclonal antibody raised against human IL16. It has been affinity purified by Protein A. IL-16 is encoded by the IL16 gene located on chromosome 15q26.3. It is initially produced as a precursor protein (pro-IL-16) that is cleaved by caspase-3 to generate the mature, secreted form of IL-16. Both pro-IL-16 and mature IL-16 are biologically active. IL-16 functions as a chemoattractant for CD4+ T cells, monocytes, and eosinophils, and can also regulate cell growth and differentiation. Increased levels of IL-16 have been associated with various inflammatory and autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and antineutrophil cytoplasmic antibody-associated vasculitis. Genetic polymorphisms in the IL16 gene, such as rs11556218, have also been linked to an increased risk of certain cancers, as well as other conditions like diabetes and osteoarthritis. Overall, IL-16 appears to play a complex role in modulating immune and inflammatory responses, with implications for both disease pathogenesis and potential therapeutic targeting.
DMAB-CBAS055 is suitable for use in ELISA(Det) application.
DMAB-CBAS055 is supplied as a liquid formulation in Phosphate-buffered saline (PBS), carrier-free, with optional 0.09% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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