Magic™ Rabbit Anti-Human IFITM2 Monoclonal antibody, clone 351429G7

Antibody Isotype

IgG

Clone

351429G7

Species Reactivity

Human

Immunogen

IFITM2 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT1127 - DMAB-CPT1128

General Notes

This product (Catalog No. DMAB-CPT1128) is a rabbit-derived monoclonal antibody raised against human IFITM2. It has been affinity purified by Protein A. IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus, by inhibiting the early steps of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in a p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also, they serve as important components of the innate immune system to restrict HIV-1 infection.
DMAB-CPT1128 is suitable for use in CBA(Det), ELISA(Det) applications.
DMAB-CPT1128 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Interferon-induced transmembrane protein 2; IFITM2; IFITM 2; DSPA2c; 240318F3; 18D; 1-8D

Entrez Gene ID

UniProt ID