General Notes
This product (Catalog No. CABT-L1515W) is a rabbit-derived polyclonal antibody raised against human GHSR1b, targeting the amino acid region 245–289 of the protein. The growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor, is a seven-transmembrane G protein-coupled receptor (GPCR) that serves as the primary mediator of the physiological effects of ghrelin, a 28-amino-acid acylated peptide hormone predominantly secreted by the stomach. Encoded by the GHSR gene located on chromosome 3q26.31, the receptor exists in two main isoforms: the full-length GHSR-1a (366 amino acids), which is the functional form coupled to Gαq/11 proteins, and the truncated GHSR-1b (289 amino acids), which lacks the full signaling capability. Originally identified as an orphan receptor for synthetic growth hormone secretagogues, GHSR was cloned from human pituitary and hypothalamic tissues in 1996, prior to the discovery of its endogenous ligand ghrelin in 1999.
CABT-L1515W is suitable for use in ELISA application.
CABT-L1515W is supplied as a lyophilized formulation. Reconstitute with 50 μl of distilled water for the equivalent of undiluted antiserum. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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