General Notes
This product (Catalog No. DPABH-02741) is a rabbit-derived IgG polyclonal antibody raised against human GHSR, targeting the amino acid region 75–135 of the protein. This antibody exhibits cross-reactivity with GHSR from mouse, rat, pig, cow, horse, rabbit, and sheep. It has been affinity purified by Protein A. This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.
DPABH-02741 is suitable for use in Western blot (WB) (1:500–1:2,000), ICC/IF (1:100–1:500), ELISA (1:5,000–1:10,000) applications.
DPABH-02741 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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