Magic™ Rabbit Anti-Human GANAB Monoclonal antibody, clone 351380C8

Antibody Isotype

IgG

Clone

351380C8

Species Reactivity

Human

Immunogen

GANAB fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT939 - DMAB-CPT940
Cytometric Bead Array: 1.25-40 ng/mL

General Notes

This product (Catalog No. DMAB-CPT939) is a rabbit-derived monoclonal antibody raised against human GANAB. It has been affinity purified by Protein A. GANAB is a human gene located on chromosome 11q12.3 that encodes the catalytic alpha subunit of the enzyme glucosidase II, a key component of the endoplasmic reticulum (ER) quality control system for glycoproteins. This subunit, part of the glycosyl hydrolase 31 family, facilitates the sequential removal of the two innermost α-1,3-linked glucose residues from the Glc₂Man₉GlcNAc₂ oligosaccharide on nascent glycoproteins, enabling proper protein folding and calnexin/calreticulin cycle participation. Glucosidase II operates as a heterodimer with the non-catalytic beta subunit encoded by the PRKCSH gene, ensuring efficient N-glycan processing essential for cellular homeostasis.
DMAB-CPT939 is suitable for use in Cytometric Bead Array (1.25-40 ng/mL) application.
DMAB-CPT939 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Alpha glucosidase 2; G2AN; GANAB; Glucosidase II subunit alpha; glucosidase, alpha, neutral AB; GluII; KIAA0088; Neutral alpha glucosidase AB

Entrez Gene ID

UniProt ID