Anti-GANAB monoclonal antibody (DCABH-6263) Knockout Validated

Rabbit anti-Human GANAB monoclonal antibody for WB, FC, IHC-P, ICC/IF

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS23487
Species Reactivity
Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human alpha Glucosidase II aa 150-250 (Cysteine residue). The exact sequence is proprietary.Database link: Q14697
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/10000; Flow Cyt: 1/10 - 1/100; IHC-P: 1/50 - 1/100; ICC/IF: 1/50 - 1/100.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
GANAB; glucosidase, alpha; neutral AB; neutral alpha-glucosidase AB; G2AN; GluII
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Neutral alpha-glucosidase AB is an enzyme that in humans is encoded by the GANAB gene. 0The function about GANAB antigen include carbohydrate binding; glucan 1,3-alpha-glucosidase activity; hydrolase activity, hydrolyzing O-glycosyl compounds.
Pathway
Asparagine N-linked glycosylation, organism-specific biosystem; Calnexin/calreticulin cycle, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; N-Glycan biosynthesis, organism-specific biosystem; N-Glycan biosynthesis, conserved biosystem; N-glycan precursor trimming, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Frederick, JR; Petri, WA; et al. Roles for the galactose-/N-acetylgalactosamine-binding lectin of Entamoeba in parasite virulence and differentiation. GLYCOBIOLOGY 15:53R-59R(2005).
Kulminskaya, AA; Saveliev, AN; et al. Human abzymes with amylolytic activity. TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY 16:17-31(2004).

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