Magic™ Rabbit Anti-Human ESR2 Monoclonal antibody, clone 351523G3

Antibody Isotype

IgG

Clone

351523G3

Species Reactivity

Human

Immunogen

ESR2 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT1103 - DMAB-CPT1104
Cytometric Bead Array: 0.781-50 ng/mL

General Notes

This product (Catalog No. DMAB-CPT1103) is a rabbit-derived monoclonal antibody raised against human ESR2. It has been affinity purified by Protein A. Estrogen receptor-beta (ESR2) is a member of the superfamily of nuclear receptors, which can transduce extracellular signals into transcriptional responses. It binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. ESR2 exists various isoforms and range of calculated molecular weight of isoforms is 50-60 kDa. The experiment detected two bands for ESR2 in isolated human germ cells, one at 60 kDa and a weaker one at 50 kDa.
DMAB-CPT1103 is suitable for use in Cytometric Bead Array (0.781-50 ng/mL) application.
DMAB-CPT1103 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

ESTRB; ERβ; ER-beta; Erb; ER BETA; estrogen receptor 2 (ER beta)

Entrez Gene ID

UniProt ID