Anti-ESR2 monoclonal antibody, clone 666DU29.6.6

Antibody Isotype

IgG1

Clone

666DU29.6.6

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:100-4000

Alternative Names

ESR2; ESTRB; NR3A2; Estrogen receptor beta; Nuclear receptor subfamily 3 group A member 2

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the family of estrogenreceptors and superfamily of nuclear receptor transcriptionfactors. The gene product contains an N-terminal DNA binding domainand C-terminal ligand binding domain and is localized to thenucleus, cytoplasm, and mitochondria. Upon binding to17beta-estradiol or related ligands, the encoded protein formshomo- or hetero-dimers that interact with specific DNA sequences toactivate transcription. Some isoforms dominantly inhibit theactivity of other estrogen receptor family members. Severalalternatively spliced transcript variants of this gene have beendescribed, but the full-length nature of some of these variants hasnot been fully characterized.

Pathway

Estrogen signaling pathway; Gene Expression; Generic Transcription Pathway; Integrated Pancreatic Cancer Pathway; Nuclear Receptor transcription pathway; Nuclear Receptors; Ovarian Infertility Genes; Plasma membrane estrogen receptor signaling;