Magic™ Rabbit Anti-Human DNase I Monoclonal antibody, clone 351333C22

Antibody Isotype

IgG

Clone

351333C22

Species Reactivity

Human

Immunogen

DNASE1 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT951 - DMAB-CPT952
Cytometric Bead Array: 0.313-40 ng/mL

General Notes

This product (Catalog No. DMAB-CPT952) is a rabbit-derived monoclonal antibody raised against human DNase I. It has been affinity purified by Protein A. Deoxyribonuclease I (DNase I), also known as DNL1 and DRNI, belongs to the DNase I family. DNase I is a DNA-digestive glycoprotein that cleaves both single- and double stranded DNA through hydrolysis of the phosphodiester bond. In humans, the DNase I enzyme is primarily secreted by the pancreas, parotid, and pituitary glands into the digestive system and bloodstream. Since DNase I is ubiquitously expressed in human tissues, it is thought to play a similar anti-autoimmune role in other organs as well (PMID: 21806320). The calculated molecular weight of DNase I is 31 kDa. Sometimes higher molecular weight around 40 kDa can also be observed, which is caused by glycosylation.
DMAB-CPT952 is suitable for use in Cytometric Bead Array (0.313-40 ng/mL) application.
DMAB-CPT952 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Deoxyribonuclease 1; deoxyribonuclease I; DKFZp686H0155; DNase I; DNASE1; DNL1; Dornase alfa; DRNI; FLJ38093; FLJ44902

Entrez Gene ID

UniProt ID